TI:Analysis on prognostic factors of liver failure in children　
AU:ZHU Shishu, ZHANG Hongfei , CHEN Jumei ,YANG Xiaojin , DONG Yi , CHEN Dawei , XU Zhiqiang
AD:Department of Pediatric Liver Diseases , The No1302 Hospital of The People’s Liberation Army , Beijing 100039 , China
【Abstract】　Objective 　To analyze the prognostic factors of liver failure in children1 Methods 　The clinical data of 105 children with liver failure treated in the No1 302 Hospital in the past 17 years were retrospectively analyzed1 The related factors were analysed by EXCELL 2000 and STATA 710 , multivariate statistical analysis was performed by Logistic regression1 Results 　(1) A total of 72 children died and the mortality was 6816 %1 (2) Univariate statistical analysis showed that the factors significantly correlated with death were age ,clinical type and stage of liver failure , decrease in prothrombin activity (PTA) and albumin (AIB) level , increase in serum level of total bilirubin (TBIL) , appearance of deviation of TBIL and ALT, complications and hepatic encephalopathy1 There was no significant difference between boys and girls1 (3) There was no significant difference among etiological diagnoses such as HBV infection , Wilson’s disease , and unknown pathogeny1 (4) Multivariate statistical analysis showed that PTA( P = 01000) and TBIL( P = 01029) were independent risk factors of mortality of the children1 Conclusion 　The prognosis of liver failure in children is poor and mortality is high1 PTA and TBIL might be useful for indicating prompt diagnosis and treatment to improve survival rate of the children with liver failure1
【Key words】　Child , preschool ; 　Liver failure ; 　Prognosis ; 　Hepatitis viruses